Bleomycin injection, blenoxanesummary of product characteristics spc accessed on 16 may 2011. Each vial contains 200 mg of dacarbazine the active ingredient, citric acid monohydrate and mannitol. Dacarbazine is approved to be used alone or with other drugs to treat hodgkin lymphoma in patients whose disease has not gotten better with other chemotherapy melanoma that has metastasized spread to other parts of the body dacarbazine is also being studied in the treatment of other types of cancer. This prescription drug comes as an injection that is given into a vein intravenously, or by iv. Dticdome dacarbazine side effects, images, uses, dosage. No dose modifications are recommended for mild to moderate hepatic impairment, but dose reduction may be considered if the patient also has renal impairment. Besides unchanged dacarbazine, 5aminoimidazole4carboxamide aic is a major metabolite of dacarbazine excreted in the urine. Find patient medical information for dacarbazine bulk on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings.
Uclh dosage adjustment for cytotoxics in renal impairment version 3 updated january2009 page 3 of 24 drug pharmacokinetics available information recommendation arsenic trioxide arsenic is stored mainly in liver, kidney, heart, lung, hair and nails. It may also be used to treat other kinds of cancer, as determined by your doctor. Dacarbazine is given into a vein intravenously, iv. Dtlc when administered in 10 times the human daily dose to male rats twice weekly for 9 weeks did not affect the male libido, although female rats mated to male rats had higher. Your doctor will determine how long to treat you with dacarbazine. The average cumulative excretion of unchanged dacarbazine in the urine is 40% of the injected dose in 6 hours. Anticancer dose adjustment for patients with renal and hepatic. Adult drugs analgesics antihypertensive and cardiovascular agents antimicrobial agents miscellaneous agents sedatives, hypnotics, and other drugs used in. Dacarbazine side effects, dosage, interactions drugs. Dosing may need to be reduced in either clinical situation. The renal drug handbook the st georges hospital, adult critical. Dacarbazine is used to treat skin cancer malignant melanoma and hodgkins disease.
Betamethasone, betaxolol, bezafibrate, bisoprolol, bleomycin, bopindolol, bretylium, brompheniramine, budesonide, bumetanide, bupropion, buspirone. Pediatric drugs analgesics antihypertensive and cardiovascular agents antimicrobial agents miscellaneous agents sedatives, hypnotics, and other drugs used in psychiatry. Preexisting hepatic disease or renal impairment can cause accumulation of the drug worsening dacarbazines toxicity. Medscape indicationspecific dosing for dtic dome dacarbazine, frequency based adverse effects. Dacarbazine is contraindicated in patients who have demonstrated a hypersensitivity to it in the past and in patients with hepatic andor renal insufficiency. Dosing guidelines book dosing guidelines for children dosing guidelines for adults. Bentyl dicyclomine hydrochloride dose, indications. Dacarbazine alkylates and crosslinks dna during all phases of the cell cycle, resulting in disruption. Since the growth of normal body cells may also be affected by. Kyowa hakko as above and bleomycin should be used with caution in patients with. Store unopened product in a refrigerator 2c to 8c 36f to 46f. The authors make no claims of the accuracy of the information contained herein. It is used to treat cancer of the lymph system and malignant melanoma a type of skin cancer.
Dtic dome dacarbazine dosing, indications, interactions. Dacarbazine dosage the recommended dacarbazine dosage will be different for each person, depending on his or her weight, the reason the medicine is being used, and a number of other factors. Uclh dosage adjustment for cytotoxics in renal impairment version 3 updated january2009 page 2 of 24 dosage adjustment for cytotoxics in renal impairment this table is a guide only. Dacarbazine dtic is the only singleagent approved by the food and drug administration for treating metastatic melanoma. After reconstitution and prior to use, the vial may be stored at 4c for up to 72 hours or at normal room conditions temperature and light for up to 8 hours. Munar, pharmd, bcps, and harleen singh, pharmd oregon state university college of pharmacy, portland, oregon.
Dacarbazine metastatic malignant melanoma nhs wales. Dacarbazine injection comes as a powder to be mixed with liquid to be injected intravenously into a vein over 1 minute or infused intravenously over 15 to 30 minutes by a doctor or nurse in a medical facility. Cetirizine, chlorothiazide, cidofovir, ciprofloxacin, cisatracurium, cisplatin, cladribine, clarithromycin, clindamycin, clonidine, codeine, cyclophosphamide. For adult soft tissue sarcomas dacarbazine is given in daily doses of 250 mgm 2 body surface area i. Preexisting hepatic disease or renal impairment can cause accumulation of the drug worsening dacarbazine s toxicity. Dacarbazine dtic is a cell cycle nonspecific antineoplastic alkylating agent used in the treatment of. During dacarbazine treatment frequent monitoring of blood counts should be conducted as well. A catalogue record for this book is available from the british library. Dacarbazine can lower blood cells that help your body fight infections and help your blood to clot. Dacarbazine is a triazene derivative with antineoplastic activity.
Dacarbazine mechanism, indication, contraindications. If the medication escapes from the vein it can cause tissue damage. Dacarbazine dacarbazine dose, indications, adverse. For hodgkins disease, you may only receive dacarbazine for 1 day every 15 days. Dacarbazine by injection national library of medicine. Dacarbazine is subject to renal tubular secretion rather than glomerular filtration. For hodgkins disease as a secondline therapy when used in combination with other agents. Dacarbazine interferes with the growth of cancer cells, which are eventually destroyed. Drug dosing adjustments in patients with chronic kidney. Dacarbazinebased chemotherapy for metastatic melanoma. Use this drug cautiously in patients with renal andor liver dysfunction. Dose reduction and close monitoring of hepatic and bone marrow function may be required. Click here for a specialized list of other renal medication dosing not listed in the alphabetical main section simple renal dosing guidelines. Dtic dome dacarbazine dosing, indications, interactions, adverse.
Dacarbazine is a structural analogue of imidazole carboxamide, a purine precursor. The plasma halflife was increased in human patients with hepatic and renal dysfunction. Dacarbazine is metabolized via hepatic pathways, so dosage adjustments may be necessary. Numerous dosing schedules exist and depend on disease. Dacarbazine fda prescribing information, side effects. An irritant is a chemical that can cause inflammation of the vein through which it is given. In the treatment of hodgkins disease, doses of 150 mg m2 daily for 5 days repeated every 4. Drug dosing adjustments in patients with chronic kidney disease myrna y. Renal impairment hepatic impairment activated and metabolised in the liver. Dticdome dacarbazine has been shown to be teratogenic in rats when given in doses 20 times the human daily dose on day 12 of gestation. Dacarbazine is a cancer medication that interferes with the growth and spread of cancer cells in the body. With dtic as single agent, an approximately 20% objective response rate can be achieved with median response duration of 5 to 6 months and complete response rates of 5%. Trivalent forms of arsenic are methylated in humans and mostly excreted in urine. Dailymed dacarbazine dacarbazine injection, powder, for.
Dacarbazine belongs to the group of medicines called alkylating agents. Dacarbazine is metabolized and eliminated through the biliary and renal systems. At therapeutic concentrations dacarbazine is not appreciably bound to human plasma protein. Dacarbazine is sometimes given daily for 5 to 10 days in a row every 3 or 4 weeks. Fda label information for this drug is available at dailymed. The level of renal function below which the dose of a drug must be reduced depends largely on the extent of renal metabolism and elimination, and on the drugs toxicity. The clinical use of dacarbazine is primarily for metastatic melanoma 69 and as a component of the avbd doxorubicin, vinblastine, bleomycin, dacarbazine regimen for treating hodgkins lymphoma. Its disappearance from the plasma is biphasic with initial halflife of 19 minutes and a terminal halflife of 5 hours. Dosage and indications dacarbazine can be dosed in dogs at 200 mgm 2 as a slow iv bolus given once daily for 5 days, or once as a slow iv infusion over 2 to 8 hours at mgm 2 every 3 weeks. Dosing guidelines book school of medicine university of. Dosage adjustment for cytotoxics in renal impairment.
Pharmacokinetic, summary of product characteristics spc, relevant pharmaceutical company data and various references have been. Dacarbazine for injection, usp is a colorless to an ivory colored solid which is light sensitive. Dacarbazine for injection, usp is reconstituted and administered intravenously ph 3 to 4. When dacarbazine is used to treat melanoma, it may be injected once a day for 10 days in a row every 4 weeks or it may be injected. It is given on a schedule as directed by your doctor. Dose reduction may be required in combined renal and hepatic impairment. Renal drug handbook gfr 2050mlsmin dose as in normal renal. Supplemental dosing is usually not required after hd.
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